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  The Role of Antiretroviral Agents in Pre and Post Exposure Prophylaxis (12HC02)

Cindy M. Hou, DO, MBA and Sindy M. Paul, MD, MPH, FACPM

Content is provided for informational purposes only.

Release Date: June 1, 2010
Expired: June 30, 2012
Activity Code: 12HC02
As seen in the June 2010 edition of  

CREDIT IS NO LONGER AVAILABLE FOR THIS ACTIVITY. If you have any questions, please email the Center for Continuing and Outreach Education at ccoereg@ca.rutgers.edu or call CCOE Enrollment Services at (800) 227-4852.



Sponsored by the University of Medicine & Dentistry of New Jersey (UMDNJ), Center for Continuing & Outreach Education, Division of AIDS Education.

Grantor Acknowledgement

This activity is supported by an educational grant from the New Jersey Department of Health and Senior Services (NJDHSS) – Division of HIV/AIDS Services through a MOA titled “Education and Training for Physicians and other Healthcare Professionals in the Diagnosis and Treatment of HIV/AIDS.” The New York/ New Jersey AETC (AIDS Education and Training Center (NY/NJAETC) provided in-kind support through the work of its Pharmacy Director, John Faragon, PharmD, BCPS, AAHIVE.

Target Audience

This knowledge-based activity is designed for physicians, nurses, pharmacists, and other health care professionals in New Jersey who are involved in the care of persons with HIV/AIDS.

Statement of Need

In the state of New Jersey, 34,712 individuals were living with HIV/AIDS as of June 2009. According to the Centers for Disease Control and Prevention (CDC), an estimated 571,378 persons are living with HIV/AIDS in the United States. The CDC estimates that 7,000 people are infected with HIV each day on a worldwide basis. The CDC estimated HIV incidence in the United States at 54,230 in 2006. With these alarming statistics, it has become especially imperative to employ existing methods of prevention along with finding new ways to prevent HIV/AIDS. In this article, we will discuss the role of anti-retroviral therapy (ART) in both pre-exposure (PrEP) and post-exposure prophylaxis (PEP). http://www.state.nj.us/health/aids/repa/aidsdata.shtml

Learning Objectives

Upon completion of this activity, participants should be able to:

  1. Explain and implement prophylaxis for prevention of maternal-to-fetal transmission of HIV.
  2. Recognize the promises and controversies behind pre-exposure prophylaxis.
  3. Apply the recommendations for prophylaxis in the event of occupational exposure to HIV-infected blood and fluids.
  4. Apply an algorithm to determine whether anti-retroviral therapies are needed for non-occupational exposures.


  • Cindy Meng Hou, DO, MBA, is an Infectious Disease Fellow with Garden State Infectious Diseases Associates, PA (GSIDA), in Voorhees, NJ, through the UMDNJ-School of Osteopathic Medicine in Stratford, NJ.
  • Sindy M. Paul, MD, MPH, FACPM, is the Medical Director of the NJ Dept. of Health and Senior Services, Division of HIV/AIDS Services; Assistant Clinical Professor at the UMDNJ School of Public Health.

Activity Director(s)/CME Academic Advisor(s)

  • Patricia Kloser, MD, MPH, Professor of Medicine, UMDNJ-New Jersey Medical School

Planning Committee:

  • Sindy Paul, MD, MPH, FACPM, NJ Dept. of Health and Senior Services
  • Debbie Y.Mohammed, MS, APRN-BC, ACRN, Nurse Practitioner, UMDNJ-University Hospital and St. Michael’s Medical Center – Peter Ho Clinic
  • Kimi Nakata, MSW, MPH, UMDNJ-CCOE-Division of AIDS Education Program Supervisor and NJ AIDSLine Editor
  • John Faragon, PharmD, BCPS, AAHIVE; NY/NJ AETC Clinical Pharmacy Director; pharmacist, Albany Medical Center

Method of Instruction

Participants should read the learning objectives and review the activity in its entirety. After reviewing the material, complete the self-assessment test which consists of a series of multiple-choice questions. Upon completing this activity as designed, achieving a passing score of 70% or more on the self-assessment test and submitting an evaluation, participants will have access to a printable online credit statement. Estimated time to complete this activity as designed is 0.75 hour for physicians and 1.0 hour for nurses.


Credit is no longer available for this activity.


This activity was peer reviewed for relevance, accuracy of content, and balance of presentation by Patricia Kloser, MD, MPH; Debbie Mohammed, MS, MPH, APRN-BC, AACRN; John Faragon, PharmD, BCPS, AAHIVE; and Brenda Christian, MEd, PA-C; Director of AIDS Education, UMDNJ-CCOE; and pilot tested for relevance and time required for participation by Kinshasa Morton, MD; Shobha Swaminathan, MD; Bonnie Abedini, MSN, RN; Mary C. Krug, MSN, APN; Kara Winslow, BSN, RN; Polly Jen, PharmD; Humberto Jimenez, PharmD, AAHIVE; and George Rusuloj, PharmD.

Disclosure Disclaimer

In accordance with the disclosure policies of UMDNJ and to conform with ACCME and FDA guidelines, individuals in a position to control the content of this education activity are required to disclose to the activity participants: 1) the existence of any relevant financial relationship with any entity producing, marketing, re-selling, or distributing health care goods or services consumed by, or used on, patients, with the exemption of non-profit or government organizations and non-health care related companies, within the past 12 months; and 2) the identification of a commercial product/device that is unlabeled for use or an investigational use of a product/device not yet approved.

Disclosure Declarations

There were no relevant financial relationships to disclose reported by the activity director, faculty, planning committee members, editor, content reviewers or field testers.

Off-Label Usage Disclosure

This activity does not contain information of commercial products/devices that are unlabeled for use or investigational uses of products not yet approved.

Content Disclaimer

The views expressed in this activity are those of the faculty. It should not be inferred or assumed that they are expressing the views of NJDHSS-Division of HIV/AIDS Services, UMDNJ, or any manufacturer of pharmaceuticals. It should be noted that the recommendations made herein with regard to the use of therapeutic agents, varying disease states, and assessments of risk, are based upon a combination of clinical trials, current guidelines, and the clinical practice experience of the participating presenters. The drug selection and dosage information presented in this activity are believed to be accurate. However, participants are urged to consult the full prescribing information on any agent(s) presented in this activity for recommended dosage, indications, contraindications, warnings, precautions, and adverse effects before prescribing any medication.

Copyright © 2010 UMDNJ-Center for Continuing and Outreach Education. All rights reserved including translation into other languages. No part of this activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval systems, without permission in writing from UMDNJ-Center for Continuing and Outreach Education. Please direct CME related questions to UMDNJ at 973-972-4267 or email ccoe@ca.rutgers.edu.


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